Introduction
The CoproStrip™ C. difficile GDH + Toxin A + Toxin B is a rapid chromatographic immunoassay combo card for the simultaneous qualitative detection of Clostridium difficile Glutamate Dehydrogenase (GDH), Toxin A and Toxin B in human feces that aids in the diagnosis of C.difficile infection.
The Savyon C. difficile (C.diff) is a triple test which allows for quick identification of the C.diff bacteria presence as well as the identification of its Toxin A and Toxin B within 10 min. The gram-positive anaerobic bacillus Clostridium difficile (C.diff) is the leading causative agent of antibiotic-associated diarrhea and pseudomembranous colitis. This pathogen is capable of causing disease that could be severe or fatal if not diagnosed on time and treated.
C.diff key virulence factors are Toxin A and Toxin B. These toxins show high sequence and functional homology. Toxin A (ToxA) has been described as a tissue damaging enterotoxin which attracts neutrophils and monocytes and Toxin B (ToxB) as a potent cytotoxin that degrades the colonic epithelial cells. Most virulent strains produce both toxins, however, Toxin A negative/Toxin B positive strains are also capable of causing disease. All strains of C. difficile produce high levels of GDH. Therefore, C. difficile’s GDH enzyme is considered a very good antigen marker for detection of this organism.
Features:
- Results obtained within 10 minutes
- Simultaneous detection of both the C. difficile antigen, Toxin A and Toxin B (3 in one)
- User friendly with minimal hands-on time. Only 1 minute of set-up
- Toxin A and Toxin B differentiation
- Compatible to the guidelines recommendation of GDH screening in combination with toxin testing to improve sensitivity.
- High performance compared to other manufacturers
- c. diff positive control set available #41220-10
- 20 Tests/kit
Cat# 41220
